The position and the scientific aim of the institute predetermine the mutual cooperation especially with universities and scientific institutions in Poland and Slovakia, but also with universities in Germany or Austria. The institute has cooperated with universities in Krakow and Wroclaw for many years. Besides the international cooperation, the institute cooperates with Silesian Municipal Museum, with other museums in the region as well as with the Institute of Archaeology of Academy of Sciences of the Czech Republic.
The scientific research is focused on archaeology of Silesia, and the institute participates in many important projects. It organises international scientific conferences, has its own library and publishes Acta Archaeologica Opaviensia.